CAVALIER Trial

The CAlcium and VAsopressin following Injury Early Resuscitation trial, or simply CAVALIER, is a research study that will look at whether giving calcium, vasopressin, or both early in the course of treatment would help severely injured patients that lose a lot of blood survive their injuries.

Normally when a person loses a lot of blood, they may receive calcium, vasopressin, or both as part of standard medical care, but not until they arrive at the hospital or are admitted to an intensive care unit (ICU). After a patient is determined to be sick enough to enroll in the study, researchers will do a randomization (like flipping a coin) to determine if the patient will receive a study drug or a placebo (salt water).